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This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. What conditions does Zoloft treat? seismist vs. flonase Jul 12, 2018. Zoloft sertraline is an SSRI antidepressant. Learn how it can help alleviate symptoms of panic disorder and what to expect while you're taking. Manufactured by Pfizer, Zoloft has been approved by the Food and Drug Administration FDA for the treatment of social anxiety disorder SAD since 2003 and is the only medication approved for long-term treatment. Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Show More Sertraline is used to treat depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder). 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