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The generic alternative is not manufactured by the company that makes the brand product. You want to plan ahead with Retin A Cream and many other acne medications because they can take up to 2 or 3 months before there’s a visible improvement. Your skin might even become worse before it gets better! As Retin A Cream is absorbed into your skin cells, it starts working on the acne that may be forming under the layers of your skin. Not to worry, it will clear as long as you are patient. When applied as directed, Retin A Cream works in your skin cells to encourage an increase in your cell turnover rate. 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