Listing a study does not mean it has been evaluated by the U. One of the mechanisms responsible for survival of these therapy-resistant hypoxic cells is (macro-)autophagy: a phenomenon in which cells provide themselves with energy (ATP) by digesting their own cell-organelles. Tumor hypoxia is a well-known factor negatively influencing outcome in many solid tumors, including small cell lung cancer. Chloroquine elimination half life Plaquenil and vuvlar lichen planus Hydroxychloroquine kidney damage A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer CUBiC The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The purpose of this study is to test the hypothesis that chloroquine will reduce the ability of ductal carcinoma in situ DCIS to survive and spread. Participants will receive either chloroquine standard dose 500mg/week or chloroquine low dose 250mg/week for 1 month prior to surgical removal of the tumor. Clinical trials are research studies that involve people. The clinical trials on this list are for colon cancer treatment. All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. Clinical trials cancer chloroquine Chloroquine in cancer therapy a double-edged sword of autophagy., Study of the Efficacy of Chloroquine in the Treatment of. Plaquenil patient reviewsDoes hydroxychloroquine have renal toxicityPlaquenil for adenomyosis Jun 22, 2018 These findings support clinical study of chloroquine to lower rates of venous thromboembolism in patients with cancer. Trial registration. This study reports correlative data from two clinical trials that registered with clinicaltrials.gov, NCT01128296 May 21, 2010 and NCT01978184 November 7, 2013. Chloroquine reduces hypercoagulability in pancreatic cancer.. Treatment Clinical Trials for Colon Cancer - National Cancer.. Re-purposing Chloroquine for Glioblastoma Potential Merits.. Hours ago During the task force briefing President Trump announced authorizing to the FDA to relax regulationsto speed up clinical trials for several anti-viral remedies to treat coronavirus. Specifically citing a therapudic drug known as chloroquine President Trump noted trials are underway and could be made available for treatment “almost immediately.” Apr 11, 2012 Chloroquine as an Anti-autophagic Radiosensitizing Drug in Stage I-III Small Cell Lung Cancer Chloroquine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Abstract. The PINC trial NCT01023477 examined the dosage efficacy of oral chloroquine CQ, an autophagy inhibitor, as a neoadjuvant therapy to reduce the volume, cause regression and decrease the recurrence of breast ductal carcinoma in situ DCIS, for any grade or ER/PR/Her2 status.