Plasmodium resistance to chloroquine

Discussion in 'Trusted Online Pharmacy' started by QuiZz, 26-Feb-2020.

  1. Weber Well-Known Member

    Plasmodium resistance to chloroquine


    Rapid diagnostic assays for Pf CRT mutations are already employed as surveillance tools for drug resistance. Here, we review recent field studies that support the central role of Pf CRT mutations in chloroquine resistance.

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    Two soldiers continued weekly prophylaxis with 300 mg chloroquine base on their return to Australia from Papua New Guinea but were not protected against Plasmodium vivax malaria. Both had symptoms and parasitaemia although plasma concentrations of chloroquine were considerably higher than those regarded as adequate for suppression of vivax malaria. INTRODUCTION WIDESPREAD resistance of malaria parasites to chloroquine has, so far, been restricted to Plasmodium falciparum. Chloroquine has remained the drug of choice for the prophylaxis and treatment of P vivax. If the patient does not respond to chloroquine, treatment should be changed to one of the two regimens recommended for chloroquine-resistant P. vivax infections, and your state health department and the CDC should be notified CDC Malaria Hotline 770 488-7788 Monday-Friday 8am to pm EST; 770 488-7100 after hours, weekends and holidays.

    Recognition of the value of chloroquine was delayed, and it was not brought forward until it was reevaluated in the United States and designated the drug of choice against malaria near the end of World War II [3]. These studies suggest chloroquine resistance arose in ⩾4 distinct geographic foci and substantiate an important role of immunity in the outcomes of resistant infections after chloroquine treatment. Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency Early in the 20th century, intense demands for an effective quinine substitute launched the discovery and evaluation of a series of organic compounds (beginning with methylene blue), which led to pamaquine and quinacrine after World War I and ultimately produced chloroquine in 1934 [1, 2].

    Plasmodium resistance to chloroquine

    Chloroquine Resistance in Plasmodium falciparum Malaria Parasites., PLASMODIUM VIVAX RESISTANCE TO CHLOROQUINE? - ScienceDirect

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  7. Unfortunately, within a decade of its introduction, P. falciparum parasite resistance to chloroquine was observed in most of the malaria-endemic countries. Nowadays, insurgence of resistance against chloroquine is a considerable hurdle for malaria control 1.

    • On the Mechanism of Chloroquine Resistance in Plasmodium..
    • CDC - Malaria - Diagnosis & Treatment United States..
    • Chloroquine - Wikipedia.

    Oct 01, 2018 Drug Resistance Resistance of Plasmodium parasites to Chloroquine is widespread see INDICATIONS AND USAGE, Limitations of Use in Malaria and WARNINGS. Plasmodium parasites exhibiting reduced susceptibility to hydroxyChloroquine also show reduced susceptibility to Chloroquine. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a carrier and which is the protonation state of its chloroquine substrate is the subject of a. We evaluated 2 drug resistance markers, the P. falciparum chloroquine resistance transporter pfcrt gene and the artemisinin resistance gene Kelch 13 k13, in malaria parasites in Haiti to determine prevalences and provide information and recommendations for clinical practice to support malaria elimination efforts.

     
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