How safe is chloroquine during pregnancy

Discussion in 'Trusted Online Pharmacy' started by Xager, 18-Mar-2020.

  1. 2SDM New Member

    How safe is chloroquine during pregnancy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is the drug of choice for the prophylaxis and treatment of sensitive malaria species during pregnancy. Chloroquine should only be given during pregnancy when need has been clearly established. See references. Chloroquine Breastfeeding Warnings. Chloroquine is excreted into human milk. Until 1995, nearly all physicians stopped hydroxychloroquine Plaquenil when a patient with lupus erythematosus LE became pregnant because there were no data on whether the drug was safe during pregnancy, said Dr. Piette of Hôpital Pitié-Salpétrière, Paris. For P. vivax or P. ovale infections, primaquine phosphate and tafenoquine for radical treatment of hypnozoites should not be given during pregnancy. Pregnant patients with P. vivax or P. ovale infections should be maintained on chloroquine prophylaxis for the duration of their pregnancy. The chemoprophylactic dose of chloroquine phosphate is.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    How safe is chloroquine during pregnancy

    The Safety of Antimalarial Drugs in Pregnancy SpringerLink, Hydroxychloroquine 'Probably Safe' in Pregnancy MDedge ObGyn

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  4. Previously mefloquine was not recommended for the treatment of malaria in pregnant women. The change in recommendations is based on the recent Food and Drug Administration FDA re-categorization of mefloquine from a pregnancy category C drug to category B, based on their review of the published data on mefloquine use during pregnancy.

    • Update New Recommendations for Mefloquine Use in Pregnancy.
    • Treatment of Malaria Guidelines For Clinicians United States - CDC.
    • Methotrexate and Pregnancy Is It Safe If You Have RA?.

    OBJECTIVE The use of hydroxychloroquine HCQ in pregnancy remains controversial. The recent demonstration that HCQ passes across the placenta, with cord blood concentrations nearly identical to those found in maternal blood, emphasizes the need for careful evaluation of pregnancies in women receiving HCQ. Researchers will compare different malaria treatments and treatment schedules which include chloroquine therapy weekly doses versus being dosed twice during pregnancy for 3 days each time to the standard practice of preventive treatment intervals in pregnancy with the drug sulfadoxine-pyrimethamine given twice during pregnancy. A baby’s body and most internal organs are formed during the first 12 weeks of pregnancy. It is mainly during this time that some medicines are known to cause birth defects. There is currently no scientific evidence to suggest that women who take chloroquine in pregnancy have a higher chance of having a baby with a birth defect.

     
  5. feleks Moderator

    Lichen planus on the skin often clears up on its own in months to years. Hydroxychloroquine 10% stop from side effects — Donovan Hair. Lichen planus - Diagnosis and treatment - Mayo Clinic Hydroxychloroquine - BAD Patient Hub
     
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