I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Plaquenil and dark spots Macular society hydroxychloroquine A lower dose may stop them. Do not lower the dose on your own. Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. You should have an eye examination every year to prevent a very rare but serious eye problem. You really should talk to your doctor about your tapering schedule and any side effects you’re experiencing. They may want you to slow down. Plaquenil can take up 1-2 months to start working and up to six months for full effect. Methotrexate strong. You were weaned off Plaquenil hydroxychloroquine and started on methotrexate. Your therapy has been escalated. The Methotrexate is working and that is good. Your doctor will be involved with you for your connective tissue disorder for a long time. Hope this helps. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Weaning off of plaquenil Stopping Plaquenil - General Discussion - Life With Lupus, Steroid treatment for RA and advice for tapering Malaria chloroquine prophylaxisMechanism of action of plaquenil Check with your doctor right away if you or your child have any of the following symptoms while using this medicine blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine. Hydroxychloroquine Oral Route Precautions - Mayo Clinic. Is it common practice to wean off plaquenil.. Will you have Weaning failure with Plaquenil - eHealthMe. Been on Plaquenil only for ten years for sarcoidosis. Once in awhile I also had to have a burst of prednisone. I have been weaning off since my sarcoidosis has been stable for eight years. I went from 400 mg. Daily to 200 daily to 200 every other day over the course of six months. I stopped it about 10 days ago and I feel like I’m 90 years old. Weaning off Flecainide Had a visit with my EP yesterday and among other discussions was that I am so off balance now I am agraid to leave the house or of course drive. After much persistence of my part asking for help he said to discontinue Flecainide, 50 Mg twice a day, for a week and see how I feel. Weaning off antidepressants, including Lexapro, Zoloft, Paxil, and others, can come with some side effects. We’ll talk about when to talk with your doctor and how to taper these medications safely.