Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Aralen medication Chloroquine resistance testing Apr 26, 2017 Alcohol can cause liver failure and cirrhosis. Methotrexate can also cause liver inflammation and fibrosis/cirrhosis. So combining the two doesn’t sound like such a hot idea. It turns out the answer to the question isn’t so black and white. Yes, alcohol can cause liver failure, however. Apr 13, 2017 NEW YORK Reuters Health—In patients taking methotrexate for rheumatoid arthritis RA, moderate alcohol consumption – that is, no higher than existing U. K. guidelines for the general population – was not associated with an increased risk of transaminitis, researchers say. Whether you take beverages shaken, stirred or decanted, mixing alcohol with methotrexate may deliver more than a hangover. Combining the two can create a cocktail muddled with serious side effects, says Junko Takeshita, M. D. Ph. D. with the department of dermatology at the University of Pennsylvania. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Methotrexate plaquenil and alcohol Is Consumption of Methotrexate With Alcohol Safe? - Health Hearty, Moderate Alcohol Use Could Be Safe with Methotrexate for RA. Plaquenil and touble eye focus The more alcoholic beverages patients with rheumatoid arthritis on methotrexate consume each week over 14 drinks, the higher the risk of liver damage in a dose dependent fashion. Dose of methotrexate was not included in the analysis so physicians should use caution in counseling patients on alcohol consumption when on higher doses of methotrexate. RA, Methotrexate and Alcohol May Mix Well, to a Degree Rheumatology.. Methotrexate and alcohol Tips for you National Psoriasis.. Moderate drinkers not at risk when taking a widely-used.. Methotrexate may cause liver problems, and using it with other medications that can also affect the liver such as ethanol may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications. DMARDs include methotrexate and Arava leflunomide, Azulfidine sulfasalazine, and Plaquenil hydroxychloroquine. Patients taking methotrexate are advised to avoid alcohol, including beer, wine, and hard liquor, because of the increased risk of liver disease. I went on 15mg methotrexate per week and 400mg plaquenil per day. Within 6 weeks all symptoms were gone, returning only twice when I was having non-related health issues that challenged my immune system. Never had drug side effects except occasional nausea; my hair has thinned but I'm in my 60's so its to be expected.