I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Hydroxychloroquine water retention Plaquenil and vitamin d Plaquenil and diahreah Hi, I JUst wanted to let you know that Plaquenil, and other lupus meds can be rough on your stomach.so in the beginning than long term. My doctor reccomended that I eat 100 calories at least prior to taking Plaquenil and Naproxen. I was prett nauseous the frist 2 weeks on these meds, but over time it diminished. By Connie Rifenburg June 3, 2015 at pm. Ang, I had hair loss pretty severe when I first started on Prednisone, Plaquenil, and Methotrexate. I guess it may depend on the dosage, and hopefully your hair loss will stop as mine did after a few months. Prednisone is the most commonly prescribed steroid for lupus. Prednisolone and methylprednisolone Medrol® are similar to prednisone. Some physicians prefer to prescribe these if you have liver problems. Most people take steroids in pill form. But, creams or gels applied to the skin are often used for cutaneous skin lupus. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Plaquenil and prednisone for lupus Lupus Medications and Treatments, Plaquenil and Prednisone What does hydroxychloroquine treatPlaquenil derived from Compare Plaquenil vs Prednisone head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Plaquenil rated 6.8/10 vs Prednisone rated 7.7/10 in overall patient satisfaction. Plaquenil vs Prednisone Comparison -. Medications used to treat lupus Lupus Foundation of America. Prednisone and Plaquenil question" Lupus Community - Support Group. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. Prednisone is the steroid most commonly prescribed for lupus. It is usually given as tablets that come in 1, 5, 10, or 20 milligram mg doses. Pills may be taken as often as 4 times a day or as infrequently as once every other day. My Mom's Dr's wan'ts her to take both Prednisone and Plaquenil together. I have not heard of this being done. I was wondering if anyone has done both med's at the same time and the effects. Mom has Lupus like me, but she was diagnosed when she was 40 yrs old and now she is 58. She has and enlarged heart, diabetes, had a stroke, and failing kidneys.