Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Sjogren's i can't tolerate plaquenil Hydroxychloroquine ingredients The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. When combined with alcohol, it is possible that certain side effects or risks of either prednisone or alcohol abuse are worsened. The Risks And Dangers Of Combining Alcohol And Prednisone. Both prednisone use and alcohol abuse have been linked to an increased risk of certain health problems. Highlights for hydroxychloroquine. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Prednisone and hydroxychloroquine interaction Prednisone and Hydroxychloroquine sulfate drug., Alcohol and Prednisone Interaction, Danger, and Side Effects Chloroquine can only be bought once a monthPlaquenil dosage sjogren& 39Plaquenil help arthritisAnti malaria pills chloroquine I started with plaquenil last year, yes it took almost 6 months to get a level in your body, it does help, trust me. I was on Prednisone 7.5 to 10 mg per day, had a bad flair up and I am on 40 mg per day, last Friday the dr.''s told me to go down by 5 mg per week, so from 40mg to 35 mg per day. Prednisone and Plaquenil question" Lupus Community.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine Side-effects, uses, time to work. Hi Helen, I am like that a lot of the time and I am on both methotrexate and prednisone. I have always put it down to lupus fogs because I have been reducing my prednisolone for the past 6 months now down to 2.5 a day maintenance dose and it still happens. Prednisone can potentially interact with certain other medications. Some of these medicines that may lead to prednisone drug interactions include Barbiturates, including Amobarbital Amytal ® Butalbital Fioricet ®, Fiorinal ® Pentobarbital Nembutal ® Phenobarbital Luminal ® Secobarbital Seconal ® Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects.