Hydroxychloroquine elevated serum porphyrin

Discussion in 'Hydroxychloroquine Plaquenil' started by black_moth, 12-Mar-2020.

  1. Dotsent Moderator

    Hydroxychloroquine elevated serum porphyrin


    These deficiencies allow heme precursors to accumulate, causing toxicity. Porphyrias are defined by the specific enzyme deficiency.

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    When used in relatively high doses, hydroxychloroquine can trigger an acute hepatic injury with sudden onset of fever and marked serum enzyme elevations with increased excretion of porphyrins. This reaction appears to be caused by the sudden mobilization of porphyrins and is often followed by an improvement in porphyric symptoms. Cutaneous porphyrias. Cutaneous porphyrias include forms of the disease that cause skin symptoms as a result of sensitivity to sunlight, but these forms don't usually affect your nervous system. Porphyria cutanea tarda PCT is the most common type of all the porphyrias. Childhood-onset porphyria cutanea tarda Successful therapy with low-dose hydroxychloroquine Plaquenil. The urinary uroporphyrin and 7-carboxylated porphyrin levels were markedly elevated along with smaller elevations of 5- and 6-carboxylated porphyrins. The fecal coproporphyrins and isocoproporphyrins were also elevated Table II.

    Heme, an iron-containing pigment, is an essential cofactor of numerous hemoproteins. Two major clinical manifestations occur: neurovisceral abnormalities (the acute porphyrias) and cutaneous photosensitivity (the cutaneous porphyrias).

    Hydroxychloroquine elevated serum porphyrin

    Low-Dose Hydroxychloroquine is as Effective as Phlebotomy in., Porphyria - Symptoms and causes - Mayo Clinic

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  4. We compared the time required to achieve a normal plasma porphyrin concentration remission, the primary outcome for 17 patients treated with phlebotomy and 13 treated with hydroxychloroquine. ResultsThe time to remission was a median 6.9 months for patients who received phlebotomy and 6.1 months for patients treated with hydroxychloroquine.

    • Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in..
    • Childhood-onset porphyria cutanea tarda Successful..
    • Porphyrins, Total, Plasma or Serum ARUP Lab Test Directory.

    The urinary uroporphyrin and 7-carboxylated porphyrin levels were markedly elevated along with smaller elevations of 5- and 6-carboxylated porphyrins. The fecal coproporphyrins and isocoproporphyrins were also elevated Table II. The porphyrin profiles of immediate family members could not be assessed because of lack of consent. Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis.

     
  5. motomax User

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Plaquenil - Lupus and Levaquin" Lupus Community - Support Group Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria
     
  6. tusja912 Moderator

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    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses