Chloroquine and primaquine malaria

Discussion in 'Hydroxychloroquine Plaquenil' started by petas, 07-Mar-2020.

  1. feedmann User

    Chloroquine and primaquine malaria


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine works best when you take it on a regular schedule. For example, if you are taking it once a week to prevent malaria, it is best to take it on the same day of each week. Make sure that you do not miss any doses. If you have any questions about this, check with your doctor. Primaquine phosphate is recommended only for the radical cure of vivax malaria, the prevention of relapse in vivax malaria, or following the termination of chloroquine phosphate suppressive therapy in an area where vivax malaria is endemic. Patients suffering from an attack of vivax Primaquine is active as a chloroquine-resistance reverser at concentrations that could be clinically relevant. As primaquine and chloroquine are already used together in the treatment of P. vivax, this is potentially a cheap way of reviving and extending the life of chloroquine.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine and primaquine malaria

    Primaquine - Wikipedia, PRIMAQUINE

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    For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended.-Current guidelines should be consulted for additional information. Usual Adult Dose for Amebiasis Prevention of relapse of P. vivax malaria. 30 mg PO qDay for 14 days with chloroquine or hydroxychloroquine. Alternatively, for mild G6PD deficiency or as an alternative to daily regimen 45 mg PO qWeek for 8 weeks use only after consultation with an infectious disease/tropical medicine expert CDC 2013. Because primaquine can cause. Primaquine is used after other medications such as chloroquine have killed the malaria parasites living inside red blood cells. Primaquine then kills the malaria parasites living in other body.

     
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