I know I had never heard of it until my rheumatologist said that is what I have...along w/osteoarthritis and fibromyalgia. My blood tests are negative for RF but my CRP test was above normal. Ai Yi Yi Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells (these are messengers for your immune system, if you will) from interacting with your T-Cells (a special type of white blood cell which through a convoluted and boring process, causes inflammation when an infection is found, and these basically malfunction with inflammatory disorders). So, he started me on 400 mg of Plaquenil a day and he just upped it to 600 mg a day. As I said previously, my Rheumatologist now says it is inflammatory osteoarthrits. Why am I taking Plaquenil, which does help tremedously BTW, if I don't have RA or Lupus. This "dendritic deactivation" (I made that phrase up) helps reduce your immune system being silly and inflaming your joints. Drug warnings for plaquenil Will plaquenil show up on a drug test What medicinescannot be taken with plaquenil Summary Spinal osteoarthritis is found among people who take Hydroxychloroquine sulfate, especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years, also take medication Fosamax, and have Osteopenia. Synovitis is believed to play a role in producing symptoms in persons with hand osteoarthritis, but data on slow-acting anti-inflammatory treatments are sparse. Objective To determine the effectiveness of hydroxychloroquine versus placebo as an analgesic treatment of hand osteoarthritis. Design Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. My sister was dx'd with Inflammatory Arthritis and Plaquenil sent her into remission some years ago now. I also take meds for high bp, asthma and high cholesterol. Hydroxychloroquine for osteoarthritis How Does Plaquenil Work For Rheumatoid Arthritis, Hydroxychloroquine to Reduce Symptoms of Hand Osteoarthritis Annals. Silver and chloroquineHydroxychloroquine does Hydroxychloroquine is primarily used to treat or prevent malaria that is caused by mosquito bites. It is not effective against chloroquine-resistant malaria strains. It can also be used in conjunction with other prescription medications to treat a variety of autoimmune diseases, including rheumatoid arthritis or lupus. What Is Hydroxychloroquine and How Does It Help Arthritis.. Treatments for Rheumatoid Arthritis. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Hydroxychloroquine is used for treatment of rheumatoid or autoimmune conditions, and osteoarthritis is more of a degenerative condition, so I can see how it may not be as effective,” she. Treatment with hydroxychloroquine HCQ in patients with osteoarthritis OA of the hands is not significantly more effective than placebo in reducing symptoms, according to a multicenter, double-blind study published in Arthritis Care & Research. Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation.