Hydroxychloroquine dose based on weight and renal function

Discussion in 'Hydroxychloroquine 200 Mg Tablet' started by wizarding, 11-Mar-2020.

  1. alcoweb Well-Known Member

    Hydroxychloroquine dose based on weight and renal function


    The chemical name for hydroxychloroquine sulfate is 2-4-[(7-Chloro-4-quinolyl)amino]pentyl]ethylamino] ethanol sulfate (1:1). Its structural formula is: The molecular weight of hydroxychloroquine sulfate is 433.95, and molecular formula is C Dibasic calcium phosphate USP, hypromellose USP, magnesium stearate NF, polyethylene glycol 400 NF, polysorbate 80 NF, corn starch, titanium dioxide USP, carnauba wax NF, shellac NF, black iron oxide NF.

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    Feb 19, 2020 Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. All patients in the cohort were prescribed hydroxychloroquine not to exceed a dose of 6.5 mg per kilogram. The maximum daily dose prescribed is 400 mg. In those who are on hemodialysis 200 mg was prescribed after each dialysis session. In those with renal insufficiency, the dose was 200mg daily.

    In the same study, the plasma peak concentration was 50.3 ng/m L reached in 3.74 hours with a half-life of 2963 hours (123.5 days). : Following a single 200 mg oral dose of PLAQUENIL to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/m L, reached in 3.26 hours with a half-life of 537 hours (22.4 days).

    Hydroxychloroquine dose based on weight and renal function

    Hydroxychloroquine Tablets - FDA prescribing information., Plaquenil Risk Calculators

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  4. Regarding the dosing of hydroxychloroquine, we advocate the use of a weight based dosing regimen with a cap at 400 mg per day, except in the case of renal insufficiency, when the dose should be reduced to 200 mg per day and for those on dialysis, who should take their hydroxychloroquine, 200 mg three times per week.

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    PrPLAQUENIL® Hydroxychloroquine Sulfate Tablets USP 200 mg ACTIONS AND CLINICAL PHARMACOLOGY PLAQUENIL hydroxychloroquine sulfate tablets belongs to the 4-aminoquinoline class. PLAQUENIL has been beneficial for patients with rheumatoid arthritis and lupus erythematosus, especially chronic discoid lupus. Annual screening is recommended in all patients who have taken hydroxychloroquine for greater than 5 years; Annual screening may be commenced before 5 years of treatment if additional risk factors for retinal toxicity exist, such as concomitant tamoxifen therapy, impaired renal function eGFR less than 60 mL/minute/1.73 m 2 or high-dose therapy greater than 5 mg/kg/day of hydroxychloroquine sulfate. Apr 03, 2016 Regarding the dosing of hydroxychloroquine, we advocate the use of a weight-based dosing regimen with a cap at 400 mg per day, except in the case of renal insufficiency, when the dose should be reduced to 200 mg per day and for those on dialysis, who should take their hydroxychloroquine at 200 mg three times per week.

     
  5. Hydroxychloroquine ototoxicity in a patient with rheumatoid arthritis. We report a case of reversible sensineural hearing loss due to hydroxychloroquine HQ treatment. The patient was a 34-year-old woman with 1 year of rheumatoid arthritis RA. She developed reversible hearing loss after 5 months of HQ treatment.

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