Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Drug interaction of chloroquine Can you have alcohol while on chloroquine Plaquenil heat The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience permanent vision loss resulting from hydroxychloroquine retinopathy due to improper dosing of the drug and improper screening. There is no single best test for detecting hydroxychloroquine toxicity. However, SD-OCT and VF are good screening tests, and FAF and mfERG can help confirm a diagnosis of suspected retinal toxicity from hydroxychloroquine. Early detection of toxicity is critical to prevent permanent visual loss. 1. Jorge A, Ung C, Young L, Melles RB, Choi HK. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Hydroxychloroquine retinal toxicity retina replacement Hydroxychloroquine-induced retinopathy in a 57-year-old woman, Retina Today - Imaging in Hydroxychloroquine Toxicity. What type of drug is hydroxychloroquineChloroquine transfection calcium phosphatePlaquenil can& 39 Retinal Toxicity The arthritis drug hydroxychloroquine can damage your retina. Your doctor may also use retinal imaging if your vision is getting worse and she isn’t sure why. Continued. Retinal Imaging Purpose, Procedure, Risks, Resutls. Hydroxychloroquine-Induced Retinal Toxicity - American.. Plaquenil Side Effects Common, Severe, Long Term -. Hui Jen Ding, Alastair K. Denniston, Vijay K. Rao, Caroline Gordon, Hydroxychloroquine-related retinal toxicity, Rheumatology, Volume 55, Issue 6, June 2016, Pages 957–967. Selective thinning of the perifoveal inner retina as an early sign of hydroxychloroquine retinal toxicity. Eye. The Risk of Retinal Toxicity with Plaquenil. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. Combining the results of examinations, HCQ retinal toxicity was deter-mined by 1 ophthalmologist, an expert in retinal diseases. The pattern of retinal toxicity was described as a parafoveal pattern, pericentral pattern, or mixed pattern of retinal toxicity, according to the location of retinal damage.