Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Cialis plaquenil Can plaquenil cause low blood pressure Could you develop a rash 3 weeks after starting hydroxychloroquine Skin side effects of plaquenil Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. If you have non-small cell lung cancer and can’t have surgery, this treatment may be an option. Your doctor guides a thin needle through your skin until it touches the tumor inside your lung. Chloroquine, a drug that has historically been used to treat malaria, has recently been combined with a new drug, Tarceva, which kills lung cancer cells. Tarceva only works for some patients, and the cancer almost always becomes resistant after prolonged exposure to the drug. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Chloroquine for lung cancer Chloroquine in Cancer Therapy A Double-Edged Sword of., Lung Cancer Treatment Options - Relapse of plasmodium vivax after chloroquine Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells Chloroquine enhances the cytotoxicity of topotecan by.. Repurposing Drugs 101 - Chloroquine & Lung Cancer. Chloroquine potentiates the anti-cancer effect of lidamycin.. Indeed, current clinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugs to inhibit autophagy during breast cancer therapy since chemotherapy and radiation, regimens that are used to treat breast cancer, are known to induce autophagy in cancer cells. The anti-authophagy drug chloroquine may be a unique way to resensitize some cancer patients to treatment. Chloroquine as an Anti-autophagic Radiosensitizing Drug in Stage I-III Small Cell Lung Cancer Chloroquine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.