It seems to me the cure is worse then the condition! Hi im starting plaquenil 200mg twice a day was wondering how far apart should the dose, be and best times to take it ,what are some of the side effects anyone has had and how long did it take to start working thank u You take plaquenil twice a day, approximately 12 hours apart. Side effects of plaquenil medication Changes in taste and smell caused by hydroxychloroquine Take Plaquenil with a meal or a glass of milk. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay and for at least 8 weeks after you leave the area. Hi Guys, I haven't been here for a while - just checked in and found this question on Plaquenil - for me it took approx nine weeks to begin to work - I'm only taking 200mg per day so far - it seemed to stop working a few weeks later - most days are pretty good I s'pose but I drop nearly every afternoon. Hi im starting plaquenil 200mg twice a day was wondering how far apart should the dose, be and best times to take it,what are some of the side effects anyone has had and how long did it take to start working thank u - thank u i wasnt sure she wanted me to have one before i started medicine but i had had one before she You can take it with food if it upsets your stomach. The most common side effect is mild nausea and occasional stomach cramps. Best way to take plaquenil Stomach problems with Plaquenil • Johns Hopkins Arthritis Center, Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly? Falciparum nf54 chloroquine Ideal time for taking Plaquenil and side effects? Discussion in 'Medications' started by ilovedisney, Apr 12, 2011. Either contact your GP or rheumy and have them explain to you the best way to take your plaq.there may very well be a good reason it has been prescribed this way. Cally x cally, Apr 12, 2011 #2. Ideal time for taking Plaquenil and side effects? Lupus.. Best time to take plaquenil - HealthBoards. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. Although there are few drug interactions with hydroxychloroquine, to be safe be sure to tell your doctor about all of the medications you are taking, including over-the-counter drugs and natural remedies. Be sure to notify your other physicians when taking this drug. May 25, 2009 You are supposed to take it after food Barb. It stands to reason that if it comes out as fast as it went in it won't get absorbed as well as it might. I had trouble with diarrhoea when I first started to take Plaquenil and that was even after food, but it wore off after several weeks. I always take it after food and have no problems now.