Chloroquine cancer

Discussion in 'Generic Chloroquine Online' started by olegator02, 15-Mar-2020.

  1. vsiakiy-vsia4in New Member

    Chloroquine cancer


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Pancreatic cancer is associated with a hypercoagulable state resulting in a high risk of venous thromboembolism VTE, which affects up to 40% of patients during their course of disease 1,2,3. Development of VTE in patients with pancreatic cancer is associated with a poor prognosis 4, 5. Despite various approaches for thromboprophylaxis, both VTE and subsequent treatments for it are. Because autophagy seems to contribute to promote cancer, chloroquine may sensitize cancer cells through inhibiting autophagy. The dosage of chloroquine usually ranges between 100 and 500 mg/day. Side effects are minimal at low doses, while many more toxic effects occur at higher doses, such as visual disturbances, gastrointestinal upset, electrocardiographic changes, headache, and pruritus.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine cancer

    Chloroquine Is a Zinc Ionophore - PubMed Central PMC, Chloroquine reduces hypercoagulability in. - BMC Cancer

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  6. Chloroquine, a drug that has historically been used to treat malaria, has recently been combined with a new drug, Tarceva, which kills lung cancer cells. Tarceva only works for some patients, and the cancer almost always becomes resistant after prolonged exposure to the drug.

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    Very basically, chloroquine interferes with a process called autophagy from the Greek “to eat oneself”. Cells use autophagy as a kind of recycling to “eat” unneeded materials, often to provide themselves with energy or other supplies needed during times of scarcity. In cancer, autophagy may help cancer cells survive chemotherapy. This drug may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes this drug by accident, get medical help right away. If your child is pregnant Tell the doctor if your child is pregnant or becomes pregnant. Chloroquine’s effects on bladder cancer cell lines, it turns out, can be shut down by providing the cells with extra cholesterol, and those effects can be recapitulated by giving them statin drugs.

     
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  8. NekrasovP Moderator

    Hydroxychloroquine - Wikipedia In 2003 a novel mechanism was described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor TLR 9 family receptors. TLRs are cellular receptors for microbial products that induce inflammatory responses through activation of the innate immune system. As with other quinoline antimalarial drugs.

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  9. ruxlik Guest

    Hydroxychloroquine safe to continue for SLE during. Of these, 118 women used the DMARD during their pregnancy or while breastfeeding, with 149 children exposed to hydroxychloroquine during the neonatal or postnatal periods. The majority of women n = 76 used the drug during pregnancy and breastfeeding, 42 during pregnancy only, and 4 only while they were breastfeeding.

    Hydroxychloroquine Side Effects, Dosage, Uses, and More