The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. In Sjogren's syndrome, the mucous membranes and moisture-secreting glands of your eyes and mouth are usually affected first — resulting in decreased tears and saliva. Your immune system mistakenly attacks your body's own cells and tissues. Plaquenil and liver Hydroxychloroquine and hearing loss Plaquenil helps me wake up early Hydroxychloroquine can cause an upset tum, it's a common side effect so it could be the longer you're taking it there's a build up effect. Trouble is you've other things coming up so it could be nervous tum, or even the two both making your tum particularly sensitive. COMMON side effects. If experienced, these tend to have a Severe expression. Azotemia. Bleeding Of The Stomach Or Intestines. Canker Sore. Decreased Blood Platelets. Hole In The Intestine. Infection Caused By Bacteria. I had a bad problem with thrush last year. Gargle meds worked bit then a week later it returned. This went on for a few months. My internist never connected it to lupus. Incidentally had an appt with rheumy. She started me in plaquenil & the thrush is gone. So far. Still get sores & a tender tongue during flares. The only thing I know is. Certain genes put people at higher risk of the disorder, but it appears that a triggering mechanism — such as infection with a particular virus or strain of bacteria — is also necessary. Scientists aren't certain why some people develop Sjogren's syndrome. Hydroxychloroquine thrush Thrush while taking Plaquenil? -, Common and Rare Side Effects for Methotrexate Anti. Plaquenil help arthritisChloroquine resistance transporterPlaquenil success rheumatoid arthritis In this review, we analyze Plaquenil side effects by the time on the drug, gender and age of the people who have side effects while taking Plaquenil. The review is based on 57,733 people who have side effects while taking the drug from Food and Drug Administration FDA. Common Plaquenil side effects a study from FDA data.. Just a cold. now oral thrush? lupus. Hydroxychloroquine Uses, Dosage & Side Effects -. Plaquenil hydroxychloroquine is a medication most known for its original purpose of treating or preventing malaria, a disease caused by parasites that enter the body through the bite of a mosquito. I have tried 3 different DMARDS over the past 5 months, Plaquenil, Sulfasalazine, & Arave. I get Thrush 2-3 wks into treatment so I stop the DMARD and treat the thrush. I am hesitant to try another DMARD because it will cause this same issue. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases.