Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Hydroxychloroquine cautions Contraindications for chloroquine How much is generic plaquenil Hi Daisy. I have had Lupus for 12yearsthat I know about and have taken Hydroxy for 10yrs It has been very succesful at keeping my lupus from getting out of hand. About a year ago i had a similar problem and was sent to a specialist for nerve tests. Thankfully the results showed no nerve damage. But the problem still existed. He told me to stop the Plaquenil because sometimes it can cause nerve damage. He told me to stop it for two weeks and come back in. He said nerve damage is a side effect. Although it is rare he has seen it happen. I was wondering if anyone else has had this happen and if the damage reversed once it was discontinued. Thanks for your repies. Feb 19, 2020 Significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate and concurrent macular disease. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Hydroxychloroquine and nerve damage Hydroxychloroquine toxicity - EyeWiki, Plaquenil and nerve damage - Scleroderma - Inspire Plaquenil steven johnson syndrome Doctors probably assumed that the nerve issues were due to the lupus in those patients. Plaquenil was never really a popular treatment. It does cause damage to the nerves in the retina for some people too.is probably an effect that was just very noticeable at first and the other nerve damage was less visible. Plaquenil causes and treats neuropathy? - NeuroTalk Support.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Plaquenil Hydroxychloroquine Sulfate. Peripheral neuropathy damage to nerves of the peripheral nervous system has been reported by people with multiple myeloma, high blood cholesterol, diabetes. Check the latest reports from 5,850 Peripheral neuropathy patients, or browse all conditions. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia.