Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil walmart Chloroquine phosphate in pregnancy JAMA. 1968 Jun 3;20410867-70. Chloroquine seizures. Report of four cases. Torrey EF. PMID 5694600 PubMed - indexed for MEDLINE MeSH Terms Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Four cases of seizures were associated with therapeutic doses of chloroquine phosphate. This is, to our knowledge, the first specific report of this side effect in the literature. Other serious side effects have been noted, especially those involving the central and peripheral nervous systems. It is. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine epilepsy Chloroquine Phosphate - WebMD, Aralen Chloroquine Uses, Dosage, Side Effects, Interactions, Warning Btk calcium chloroquinePlaquenil and methotrexate taken togetherPlaquenil hyperpigmentation Oct 01, 2018 Since Chloroquine phosphate tablets are known to concentrate in the liver, it should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs. Central Nervous System Effects Chloroquine may increase the risk of convulsions in patients with a history of epilepsy. Drug Interactions Chloroquine - FDA prescribing information, side effects and uses. Chloroquine Seizures Report of Four Cases JAMA JAMA Network. Chloroquine C18H26ClN3 - PubChem. Doses expressed as chloroquine base. Each tablet contains 155 mg of chloroquine base equivalent to 250 mg of chloroquine phosphate. Syrup contains 50 mg/5 mL of chloroquine base equivalent to 80 mg/5 mL of chloroquine phosphate. Patients with history of epilepsy should be advised about the risk of chloroquine provoking seizures. Drug Interactions. Antacids and kaolin Antacids and kaolin can reduce absorption of chloroquine; an interval of at least 4 hours between intake of these agents and chloroquine should be observed. Three cases are reported of patients developing seizures whilst taking chloroquine. Recently, eight such cases have been reported elsewhere. A review of all patients described in the literature is given. Possible relationships between chloroquine and the occurrence of seizures are discussed and further studies recommended.