Mechanism of action of chloroquine pdf

Discussion in 'Chloroquine Phosphate 500 Mg' started by AlexGG, 08-Mar-2020.

  1. Shpak Moderator

    Mechanism of action of chloroquine pdf


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Mechanism of Action Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain. Chloroquine resistance is associated with a decrease in the amount of chloroquine that accumulates in the food vacuole, the site of action for chloroquine. The mechanism for this decreased accumulation is controversial. Some studies have shown that the decrease in drug accumulation is due to an increase in drug efflux.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Mechanism of action of chloroquine pdf

    Chloroquine Modes of action of an undervalued drug., Chloroquine - FDA prescribing information, side effects and uses

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  5. Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. It was the drug of choice to treat malaria until the development of newer antimalarials such as pyrimethamine, artemisinin, and mefloquine. Chloroquine was granted FDA Approval on 31 October 1949.

    • Chloroquine - DrugBank.
    • Mechanisms of drug action and resistance.
    • Mechanisms of action of hydroxychloroquine and chloroquine..

    Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of 3Hchloroquine and 3H quinidine. These 3Hquinoline compounds became associated with hemozoin. Effects of chloroquine? Chloroquine is a relatively well-tolerated. medicine. The most common adverse reactions reported are stomach pain, nausea, vomiting, and headache. These side effects can often be lessened by taking chloroquine with food. Chloroquine may also cause itching in some people. All medicines may have some side effects. Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products.

     
  6. lurik XenForo Moderator

    Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Hydroxychloroquine Plaquenil Dosing Calculator - MDCalc Plaquenil Risk Calculators Hydroxychloroquine retinopathy Eye
     
  7. ants User

    Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Chloroquine Dosage Guide with Precautions - Medicines for the Prevention of Malaria While Traveling. Instructions for Bowel Preparation with Antibiotics
     
  8. shushik Moderator

    Methotrexate in Patients With Scleroderma/CREST Syndrome Methotrexate in Patients With Arthralgias in Scleroderma/CREST Syndrome - Medscape - Nov 17, 2005. Tables. Authors and Disclosures. Authors and Disclosures.

    CREST Syndrome Background, Pathophysiology, Etiology
     
  9. boo! Guest

    Plaquenil - Uses, Side Effects, Interactions - Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints.

    Hydroxychloroquine Uses, Dosage & Side Effects -