The cramping, cold sweats, and explosive diarrhea was unimaginable. Its my classic reaction to all new psych drugs and new antiseizure drugs, including neurontin. It is a pain in the you kno what, but I have to do what I have to do! I thought I was going to pass out the pain was so bad. Plaquenil itself I've never had an issue with, but there was a med I was given for a UTI that I didn't know was NOT supposed to be with food that gave me that kind of reaction. I wasn't too bad with Plaquenil until I doubled the dose a few weeks ago to 400mg. Mefloquine lariam and chloroquine Difference between plaquenil and methotrexate Plaquenil for lupus mechanism I suspect plaquenil for giving me some episodic diarrhea. I am 100 mg dose and take it with my supper. Did they happen to anyone else and did it eventually stop with the diarrhea side effect? It helps so much with the fatigue and pain. I have a sensitive stomach and perhaps I shouldn't have eaten that salad for lunch yesterday. To check all the drugs that have ingredients of hydroxychloroquine sulfate and Diarrhea Diarrhea and drugs with ingredients of hydroxychloroquine sulfate 3,169 reports How severe was Diarrhea and when was it recovered Diarrhea in Plaquenil RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Hopefully, it's like Lynwood said - a one time anomaly. I didn't think it was going to be like this though! I really have to shift the burden off my liver whenever I can. Love, Marji I am going on week three with the plaq and I have worked out a little routine. I did give myself a much needed cleanse though..... You might want to check the website it's a great drug interaction website that also checks some foods & seasonings Sorry you had that nasty episode, I bet it's a one-time combo of some kind that did you in. Then I had explosive diarrhea I've settled down a bit but about once a week I have a really bad blow out. But I'm starting to feel a lot better with my other symptoms, so a little digestive discomfort is worth it I suppose. Can hydroxychloroquine cause diarrhea Hydroxychloroquine Pediatric Medication Memorial Sloan., Will you have Diarrhea with Plaquenil - eHealthMe Plaquenil pregnancy category arthritisChloroquine half life mousePlaquenil 200 mg dailyChloroquine dosing for ophthalmologyChloroquine resistance mechanism of action Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Plaquenil Side Effects Common, Severe, Long Term -. Common and Rare Side Effects for Plaquenil Oral. Common and Rare Side Effects for Hydroxychloroquine Oral. Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. I can only tolerate one 200mg dose of plaquenil a day. I allergic to sulfa, and the full does causes my skin to break out in an itchy burning rash from scalp to toes, and everywhere in between. So, I do not have stomach issues, probably because of that. However, the methotrexate does cause some intestinal distress the following day. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.