It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Reviews on plaquenil Plaquenil hydroxychloroquine alternative medicine Withdrawal symptoms happen only after you stop taking a medicine. Side effects happen when you’re using it. If you’ve taken Adderall for a long time or have misused it, you might have one or. Plaquenil hydroxychloroquine takes a long time to get out of the system - up to 18 months. Be certain you and your physician agree you should discontinue it. HealthTap does not provide medical advice, diagnosis, or treatment. For these services, please use HealthTap Prime or Concierge. See Additional Information. I recently decided to stop taking Plaquenil because I was having constant chest pains even more so than I usually have due to Lupus. Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Hydroxychloroquine comes as a tablet to take by mouth. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. What happens if you suddenly stop taking plaquenil Can you just stop taking plaquenil or do you have to wean off., What happens if I stop taking plaquenil hydroxychloroquine suddenly. Hydroxychloroquine risks Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Had to stop taking Plaquenil -. What is the correct way to discontinue use of plaquenil?. I've stopped and started a couple of times, always with the blessing and knowledge of my doctor. I was told I didn't have to taper it like prednisone, and that I shouldn't expect any rebound type of reaction like you get when your body adjusts to being off pred. One of the problems with Plaquenil is that because it's so slow to act, the improvements are also slow and subtle. So most people don't realize that they've improved until they STOP taking it. I've been on it twice, along with Atabrine another antimalarial. In my case, it never worked so I didn't notice a change. Withdrawal symptoms usually start when 90% of the drug has left your body. 3 In a case study published in 1999, a man who abruptly stopped using bupropion did not experience any withdrawal symptoms until 5 days after his last use. These symptoms included irritable mood, insomnia, anxiety, headache, and aches and pains.