It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Why is plaquenil so expensive Benlysta vs plaquenil Definition The major histocompatibility complex locus designated HLA-DR4 was first associated with RA in studies reported by Stastny in 1978. Using the technique of mixed lymphocyte culture, patients with RA were found to be more alike than were normal individuals, suggesting the presence of a shared cell-associated antigen. Rheumatoid Arthritis RA Rheumatoid arthritis RA is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. Inherited susceptibility to rheumatoid arthritis RA is associated with the DRB1 genes encoding the human leukocyte antigen HLA-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex MHC class II molecules. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hla-dr4 rheumatoid arthritis and hydroxychloroquine RA and Hydroxychloroquine How Effective is it for., Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Herpes and plaquenilHydroxychloroquine reviews ukPlaquenil during pregnancy HLA-DR4 DR4 is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world. HLA-DR4 - Wikipedia. Association of MHC and rheumatoid arthritis HLA-DR4 and.. Hydroxychloroquine Plaquenil. Jul 11, 2017 Introduction. Rheumatoid arthritis RA is a chronic auto-inflammatory disease that primarily affects the joints. Worldwide the prevalence ranges between 0.5 and 1% with a few populational exceptions and a higher occurrence in females than in males Silman & Pearson, 2002. Dec 29, 2009 Hydroxychloroquine Plaquenil, an antimalarial drug used in lupus and rheumatoid arthritis, may be helpful in some patients with SjÃ¶gren's syndrome by reducing joint pain and rash. Plaquenil is a DMARD which has been prescribed for years to treat rheumatoid arthritis, lupus, juvenile rheumatoid arthritis, and other autoimmune diseases. When the first biologic DMARD received FDA-approval in 1998, and as other biologics followed in subsequent years, it appeared as though Plaquenil would become less prescribed.