Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Is quinolone related to plaquenil Plaquenil oct flying saucer Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. We show that CQ mainly inhibits autophagy by impairing autophagosome fusion with lysosomes rather than by affecting the acidity and/or degradative activity of this organelle. Furthermore, CQ induces an autophagy-independent severe disorganization of the Golgi. Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus. Application DNA intercalator. Also used to increase transfection efficiency. Chloroquine diphosphate salt has been used • in in vitro antiplasmodial assays Here, we show that the clinically used anti-malarial drug chloroquine CQ, an inhibitor of lysosomal function and autophagy, decreases T-ALL cell viability and proliferation. This effect of CQ was not observed in GSI-resistant T-ALL cell lines. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Cq chloroquine Autophagy inhibitor chloroquine induces apoptosis of., Chloroquine diphosphate salt powder or crystals, 98.5-101. 200 mg plaquenil Chloroquine-Sensitive Zones Chloroquine is the drug of choice for travel to areas where chloroquine resistance has not been described. Chloroquine is active against the erythrocytic forms Fig. 6.3 of sensitive strains of all species of malaria, and it is also gametocidal against P. vivax, P. malariae, and P. ovale. Chloroquine - an overview ScienceDirect Topics. Chloroquine & Hydroxychloroquine supporting chemo.. Chloroquine - Wikipedia. Chloroquine per week starting at least 1 week before. traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 300mg base 500mg salt. Chloroquine is currently approved by the U. S. Food and Drug Administration FDA for the treatment of malaria and certain amoeba infections. 5 Researchers have evaluated whether chloroquine can reduce immune system hyperactivity also called immune activation as part of a strategy to treat or cure HIV infection. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis.