No clinical trials of medications for ch ILD have been conducted to date. Corticosteroids have been the mainstay of therapy in most children and adults with interstitial lung disease (ILD), despite little conclusive evidence of their efficacy. Plaquenil and citalopram use cause qt prolongation Hydroxychloroquine liver toxicity Childhood interstitial lung disease due to surfactant protein C deficiency frequent use and costs of hospital services for a single case in Australia Neil J Hime 1, 2 Dominic Fitzgerald 2, 3 Before using hydroxychloroquine, tell your doctor if you are allergic to any drugs, or if you have psoriasis, porphyria, liver disease, alcoholism, or glucose-6-phosphate dehydrogenase G-6-PD deficiency. Call a poison control center at once and then seek emergency medical attention if you think you have used too much of this medicine. Surfactant protein C, which is expressed as a pro-protein in AEC2s, is critical for surfactant homeostasis. Mutations in SFTPC result in the production of an abnormal pro-protein that accumulates in AEC2s. Chloroquine or hydroxychloroquine has been previously reported to improve symptoms in patients with surfactant protein C dysfunction. Hydroxychloroquine 200mg twice daily was added to his regimen, and his prednisone dose has been tapered to 15mg daily over the subsequent three months. These agents elicit anti-inflammatory properties and cause profound and varied metabolic effects. The medications commonly used for pharmacotherapy in ch ILD and common adverse effects are reviewed below. Hydroxychloroquine surfactant protein c deficiency Surfactant Deficiency Causes & Reasons - Symptoma®, Hydroxychloroquine Uses, Dosage & Side Effects - Hydroxychloroquine risksHydroxychloroquine blocks tlfPros of chloroquinePlaquenil vs rituximab rituxan Subsequently, surfactant protein gene analysis revealed mutations in the ABCA3 gene. This case of ABCA3 deficient ILD describes a stable clinical course over 10 years and highlights the potential benefit of hydroxychloroquine for this condition. Pediatr Pulmonol. 2014; 9–301. Ten-year follow up of hydroxychloroquine treatment for ABCA3.. Recurrent diffuse lung disease due to surfactant protein C.. Successful treatment of neonatal respiratory failure.. Summary. The clinical course and treatment in the first 2.5 years of life of a term-born girl with a severe onset of respiratory symptoms in the neonatal period caused by a p. Cys121Phe/C121F mutation in the gene of surfactant protein C SFTPC is described. During the first 9 months of life, she was mechanically ventilated. Chest Radiographs and a CT Scan in a Boy with Surfactant Protein C Deficiency Treated with Hydroxychloroquine. Panel A shows a chest radiograph and Panel B a CT scan obtained at the initiation of. Focusing on immunomodulation and aggressive anti-inflammatory therapy, a triple-drug combination was chosen with hydroxychloroquine, azithromycin, and methylprednisolone pulse based on sporadic success in surfactant protein C deficiency.