Acute chloroquine toxicity

Discussion in 'Canadian Pharmacies' started by Elimelech, 23-Feb-2020.

  1. fox2305 Guest

    Acute chloroquine toxicity


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Commonly used on holidays in malaria prone destinations, chloroquine and hydroxychloroquine will not be over familiar to the emergency physician. However, it is one of the leading causes of drug overdose in malaria prone countries and also the occasional toddler has managed to consume the grandparents lupus or rheumatoid arthritis medication leading to lethal consequences. CONCLUSIONS The mortality rate in patients with acute chloroquine poisoning, including those patients sick enough to be referred to a specialty unit such as ours, can be limited to or = 10%. This finding appears to be true even in patients with massive ingestions. Children aged under 6 years of age should not be given chloroquine due to the risk of overdose and acute toxicity. The chloroquine dose should be reduced in patients with renal disease, as up to 70% of chloroquine is excreted unchanged in the urine. Chloroquine itself can cause reduced kidney function of up to 10% of patients, especially in those over 60 years of age.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Acute chloroquine toxicity

    Chloroquine and Hydroxychloroquine Toxicity Guidelines., Treatment of acute chloroquine poisoning a 5-year experience.

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  7. The mechanism of chloroquine and hydroxychloroquine toxicity is not well understood. Chloroquine has an affinity for pigmented melanin-containing structures, which may explain its toxic properties in the eye. Melanin serves as a free-radical stabilizer and can bind toxins, including retinotoxic drugs.

    • Chloroquine and Hydroxychloroquine Toxicity Practice..
    • Chloroquine DermNet NZ.
    • Hydroxychloroquine toxicity - EyeWiki.

    Oct 01, 2018 Do not use Chloroquine phosphate tablets for the treatment of complicated malaria high-grade parasitemia and/or complications e.g. cerebral malaria or acute renal failure. Do not use Chloroquine phosphate tablets for malaria prophylaxis in areas where Chloroquine resistance occurs, Resistance to Chloroquine phosphate tablets is widespread in. Chloroquine CQ and hydroxychloroquine HCQ are anti‐rheumatic medications frequently used in the treatment of connective tissue disorders. We present the case of a 45‐year‐old woman with CQ‐induced cardiomyopathy leading to severe heart failure. None. One hundred sixty-seven consecutive patients with acute chloroquine overdose admitted to our toxicology ICU. The mean amount ingested by history was 4.5 +2- 2.8 g. and 43 26% of 167 patients ingested 5 g. The mean blood chloroquine concentration on admission was 20.5 +/- 13.4.

     
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    My husband has been taking Plaquenil (generic hydroxychloroquine) for almost 2 yrs., under a rheumatologist's care. He became very ill, and was diagnosed w/ viral meningial encephalitis. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Plaquenil Oral Uses, Side Effects, Interactions, Pictures. The Risk of Retinal Toxicity with Plaquenil
     
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