Chloroquine and brain cancer

Discussion in 'Canadian Pharcharmy' started by Zheka_H, 18-Mar-2020.

  1. Cossack XenForo Moderator

    Chloroquine and brain cancer


    Now a paper published January 17 in the journal describes a new drug combination that has stabilized Rosendahl's disease and increased both the quantity and quality of her life: Adding the anti-malaria drug chloroquine to her treatment stopped an essential process that Rosendahl's cancer cells had been using to resist therapy, re-sensitizing her cancer to the targeted treatment that had previously stopped working. Along with Rosendahl, two other brain cancer patients were treated with the combination and both showed similar, dramatic improvement.

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    There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers. While there is considerable evidence for the efficacy and. SIGNIFICANCE Autophagy inhibition may improve cancer therapy, but it is unclear which tumors will benefi t. We found that BRAF mutations cause brain tumor cells to depend on autophagy and display selective chemosensitization with autophagy inhibition. We present a pediatric case in which deliberate This medicine may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects.

    They tested it for cancer and it came back positive," Lisa says. "When I was 21 they found a large mass in my brain and I had it resected right away.

    Chloroquine and brain cancer

    Vascular Protection by Chloroquine during Brain Tumor Therapy with Tf., Autophagy Inhibition Improves. - Cancer Discovery

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  4. Chloroquine, or Chloroquinone, is an anti-malaria drug that can be repurposed for use in oncology, as it can reduce tumour growth, proliferation and metastasis; it also seems to increase the effectiveness and longevity of chemotherapy drugs such as temozolomide and is particularly potent against BRAF and p53 deficient cancer cells.

    • Repurposed malaria drug Chloroquine effective with certain..
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    • Chloroquine - Cancer Therapy Advisor.

    The anti-malaria drug chloroquine has now been used as a last resort on three brain cancer patients, and in each case, it seems to have overcome the cancer's resistance to traditional treatments. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Nov 15, 2015 Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested.

     
  5. defender#2 New Member

    Plaquenil, hydroxychloroquine (HCQ), is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory and autoimmune diseases. Retinal Physician - Hydroxychloroquine Maculopathy An Update. Hydroxychloroquine - an overview ScienceDirect Topics Retinal Toxicity Associated With Hydroxychloroquine and.
     
  6. Never Moderator

    Click to enlarge Autophagy is an orchestrated homeostatic process to eliminate unwanted proteins and damaged organelles. Autophagy Inhibitors - Autophagy Sigma-Aldrich Autophagy Tocris Bioscience Approved drugs found to induce autophagy Huntington's.
     
  7. maratzabbarov XenForo Moderator

    Early paracentral visual field loss in patients taking. Patients taking hydroxychloroquine can demonstrate a toxic reaction in the retina despite the absence of known risk factors. Screening, including Humphrey 10-2 visual field assessment, is recommended 2 years after the initial baseline and yearly thereafter.

    Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy