Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil and statins Plaquenil drug card The study was a Kaiser Permanente retrospective case-control study that examined 2361 patients who had used hydroxychloroquine continuously for at least 5 years according to pharmacy records and who were evaluated with visual field testing or spectral-domain optical coherence tomography. New research finds that measuring blood levels of the medication hydroxychloroquine Plaquenil in people with lupus may be an effective way to predict risk of retinopathy, a disease which results in impaired or complete loss of vision. The study assessed 537 people with lupus and measured the levels of the drug present in their blood. Mar 02, 2018 The new guideline on screening for hydroxychloroquine and chloroquine retinopathy is written in response to evidence from the United States that shows that hydroxychloroquine retinopathy is more common than previously recognised. Implementation of the guideline’s recommendations will prevent iatrogenic visual loss. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Reading oct screening results plaquenil RheumNow Hydroxychloroquine Blood Levels in SLE MedPage Today, Study Finds Blood Levels of Plaquenil may be Important. Is plaquenil safe for kidney diseaseHydroxychloroquine sulfate hcqSle hydroxychloroquineChloroquine phosphate 250 mg dayPlaquenil sjogren& 39 The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience. Despite Plaquenil dosing recommendations, retinal toxicity.. RCOphth guideline Hydroxychloroquine and Chloroquine.. OCT Protocols for Screening of Hydroxychloroquine Retinopathy.. Optical Coherence Tomography. A Clinician‟s Guide to Retinal Scan Interpretation. by. Brandon Reed, B. S. & Dave Glabe, B. S. This tissue often results in abnormal displacement of the internal limiting membrane ILM as well as more outer retinal layers, and may cause a corresponding decrease in visual acuity and metamorphopsia. On OCT. However, your decision should also take into account the normal variability between each visual field, the optic nerve head appearance, pressures, patient compliance, OCT, visual symptoms, etc. This is a very complex topic and somewhat beyond the discussion of this post, so talk to your seniors and your attendings if you aren’t sure! Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is.