Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hydroxychloroquine and folic acid Generic plaquenil manufacturers Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. Oct 12, 2009 As I thought about it, I realized that many other small activities that had hurt before were no longer so painful. I had that same experience of having to stop taking it for a while, and the joint aches returned very quickly. The fatigue is better on the Plaquenil, but it doesn't take much for me to overdo it. I really have to pace myself. Nov 14, 2006 Someone else told me that plaquenil could take up to a year to work. Others have told me that it only took a few months for them to feel the effects. Everyone is different. I can tell you that plaquenil is the safest of all of the DMARDs. If you're going to stay on a DMARD for a long time, plaquenil is the one to be on. Best of luck on the. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. How long before plaquenil works PLAQUENIL" Rheumatoid Arthritis Community - Support Group, Plaquenil - How long to take effect? Hydroxychloroquine cheapSide effects of malaria pills chloroquine Jan 29, 2007 Irene, I read your post and it sounds like something I have been through before. I have been on Plaquenil for a long time now and just last summer I found out how sensitive it makes your skin in the sun. Coming Off Plaquenil questions - Sclero Forums MAIN.. Plaquenil -. How long does it take for plaquenil to work - Answers. Aug 29, 2014 One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. I am having severe RA again in my feet and ankles. Happens about at the end of every month now. Even since I've started the meds. I am on Plaquenil right now, but I am wondering how well it works since my pain has come back. I have heard some people switch over to Methotrxate if the Plaquenil doesn't work. 4 replies Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives.