In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Effects of plaquenil on vision Plaquenil uk Plaquenil itself probably does not have a direct affect on your immune system - it is a DMARD and is not considered to be an immunosuppressant. However, many with active autoimmune diseases feel that they are not succeptible to many of the common viruses that they are exposed to - somewhat of a silver lining. Which is what its supposed to do. I went additionally on Imuran about 8 weeks ago and have had more drastic symptom reduction, but that's because Imuran is an immune suppressants whereas plaquenil is an immune modulator/anti malarial. As a heads up plaquenil took 14 weeks for me to feel the full effects. Aug 27, 2014 Cookiiez95 - I tried plaquenil for 6 months on top of methotrexate rheumatoid arthritis + other autoimmune diagnoses and saw no benefit, but don't recall having negative side effects, either. It also failed to help my mom, who was on it for years, despite its failure to help. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. What does plaquenil do for autoimmune diseases What exactly does Plaquenil do. - Sjogren's World, Does Plaquenil actually work for you? autoimmunity Tbe chloroquine gel Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. Hydroxychloroquine Plaquenil. Plaquenil - @Cookiiez95 - Autoimmune diseases - 20140827.. Taking Plaquenil for Rheumatoid Arthritis. The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Aug 02, 2010 1. Yes, Plaquenil suppresses the immune system. Autoimmune disease such as Sjogrens occurs when the body gets "confused" and attacks healthy tissue instead of just attacking the germs. Basically, the immune system is a bit out of control. Plaquenil works by suppressing the immune system. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others.