This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Lichen planus hydroxychloroquine Hydroxychloroquine for lichen planus Cardiac Effects Cases of cardiomyopathy resulting in cardiac failure, in some cases with fatal outcome, have been reported in patients treated during long term therapy at high doses with Chloroquine see ADVERSE REACTIONS and OVERDOSAGE. Monitor for signs and symptoms of cardiomyopathy and discontinue Chloroquine if cardiomyopathy develops. Some side effects of chloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. You may report side effects to FDA at 1-800-FDA-1088. Back to Top. Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Chloroquine long term side effects Side Effects of Chloroquine and Primaquine and Symptom., Chloroquine Side Effects Common, Severe, Long Term. Sun sensitivity plaquenilPlaquenil and acetaminophenPlaquenil withdrawal symptomsHydroxychloroquine cost in indiaChloroquine for giardiasis In 2005, Lareb, the Netherlands Pharmacovigilance Centre, reported that it received three reports of permanent hearing loss and tinnitus after long-term Plaquenil use. The article mentioned that hydroxychloroquine is chemically related to other drugs that have known toxic effects on hearing 2. Other Side Effects Long-Term Side Effects of Plaquenil for Rheumatoid.. Hydroxychloroquine - Side Effects, Dosage, Interactions.. Chloroquine Oral Route Side Effects - Mayo Clinic. The drug chloroquine has long been used to treat malaria, but it is not without side effects. Chloroquine kills malaria by causing the pH in certain parts of the parasite's cell to increase. A comprehensive guide to side effects including common and rare side effects when taking Plaquenil Hydroxychloroquine includes uses, warnings, and drug interactions. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. There is rational, pre-clinical evidence of effectiveness and evidence of safety from long-term clinical use for other indications to justify clinical research on chloroquine in patients with.