The main finding in scleroderma is thickening and tightening of the skin and inflammation and scarring of many body parts, leading to problems in the lungs, kidneys, heart, intestinal system and other areas. Twins and family members of those with scleroderma or other autoimmune connective tissue diseases, such as lupus, may have a slightly higher risk of getting scleroderma. There is still no cure for scleroderma, but effective treatments for some forms of the disease are available. Children can also develop scleroderma, but the disease is different in children than in adults. Chloroquine high creatinine Hydroxychloroquine dialysis Because no two cases of Scleroderma are alike, identifying your disease subtype, stage, and involved organs is very important in determining the best course of action for treatment. Current therapies use medications that focus on the four main features of the disease inflammation, autoimmunity, vascular disease, and tissue fibrosis. I've had a CREST diagnosis for 10 years now and she mentioned at our last visit that she feels I don't have that, but have Sjogren's instead. Mind you I have no dry eyes, mouth, or anything else. And I consistently test positive with the anticentromere pattern. And I have the R, S, and T of CREST. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. A great deal of research is also underway to find better treatments for scleroderma and, hopefully, someday a cure. Although the underlying cause is unknown, promising research is shedding light on the relationship between the immune system and scleroderma. Hydroxychloroquine for crest syndrome Prognosis and treatment of mixed connective tissue disease., Plaquenil--used To Treat Crest? - Sclero Forums MAIN. Chloroquine fansidar and mefloquineDrug information about chloroquineHow does plaquenil helpPeople on plaquenil Jan 22, 2016 I was 55 when diagnosed with "CREST" in 2000 & started on Plaquenil & a since withdrawn NSAID. My early symptoms in addition to abnormal labs were severe fatigue, joint pain mainly in lower body - legs & hips, reflux & Raynauds. Just Diagnosed with Crest Syndrome & Prescribed Plaquenil.. Hydroxychloroquine MedlinePlus Drug Information. Hydroxychloroquine Dosage Guide with Precautions -. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for. But the clear link between tryptophan and eosinophilia myalgia syndrome and the scleroderma-like disease associated with contaminated rapeseed oil ingestion raise the possibility that exposure to something in the environment could trigger scleroderma. Symptoms. The symptoms of scleroderma vary from person to person and can include For months now my skin has been thickening I have now reached the point where I feel as though my arms are going to split like a sausage and been extremely inflamed and painful. A month ago I started on Plaquenil and prednisolone. It has helped a bit with the inflammation but on reading various.