I had some of the usual problems with the upset stomach at the beginning but it got better with time. Over the last 8-10 weeks I have noticed that I have been getting very dark circles under my eyes which starts at the inner corner of my eye. Chloroquine phosphate in myocardial protection Hydroxychloroquine bleaching cream Hydroxychloroquine pigmentation histology Common, nonocular, side effects of chloroquine and hydroxychloroquine include pruritus, headaches, dizziness, and gastrointestinal upset. Less frequent side effects include discoloration of the oral cavity, nails, skin and hair and rash. HCQ myopathy is uncommon and presents with proximal muscle weakness and rarely ventilatory failure. Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ. Skin pigmentation related to use of hydroxychloroquine starts out as a yellow brown to slate gray or black pigmentation on many areas of the body - especially the front of the shins but also the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds. How common is it? I thought it was because I was not doing very well for a couple of weeks.... When I looked closer the skin is a little red with a bluish black color like a bruise. Gray nails and plaquenil Skin Discoloration and Plaquenil - Arthritis Information, Hydroxychloroquine-Induced Pigmentation in Patients With Systemic Lupus. How to pronounce chloroquineWhat is plaquenil made ofH-chloroquineCan you breastfeed while on plaquenil Increased pigmentation in the skin – usually blue-gray to black discolouration can appear on the skin especially over sun-exposed areas such as the face and shins as well as on the nails and oral palate. • Other skin rashes. • Bleaching of the hair roots or hairloss – usually reversible. Plaquenil - SouthDerm. Skin Pigmentation with Hydroxychloroquine Plaquenil.. Finishing Nails - Nails - The Home Depot. I was diagnosed with Raynauds in 1998. I was told it was severe by a Vascular Surgeon. I don’t have spells, mine is constant my nails are gray and I have modeling on the upper parts on my fingers and my full toes. My skin around my toenails has had ulcers due to the Raynauds. I take Cialis daily to help with blood flow. Nonmelanic pigmentation occurs when the nail matrix extracts the drug and stores it in the nail, or the drug deposits in the nail or subungual area. The nail may turn blue, brown, or gray, depending on the drug, and the color will grow out as the nail does. 1,20,21; Irritant or allergic reactions. Topical agents sometimes cause nail changes. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur.