Plaquenil prevents lupus anticoagulangpt antibodies

Discussion in 'Canadian Drug' started by Alexey_NP, 29-Feb-2020.

  1. giorgio Guest

    Plaquenil prevents lupus anticoagulangpt antibodies


    When you have this condition, your body's immune system makes abnormal proteins that attack the blood cells and lining of the blood vessels. The presence of these antibodies can cause problems with blood flow and lead to dangerous clots in blood vessels throughout the body. Both certain gene changes and other factors (such as an infection) may cause the problem to develop.

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    Antiphospholipid antibodies which include the lupus anticoagulant, anticardiolipin antibodies, and antibodies to B2 glycoprotein I can interfere with the function of the placenta, usually during the second trimester, by causing blood clots that prevent the placenta from growing and functioning normally. This can slow fetal growth. These antibodies — also known as lupus anticoagulants due to their prevalence in patients with systemic lupus erythematosus — are extremely heterogeneous and are directed against a wide variety of anionic phospholipids, including cardiolipin, ß2 glycoprotein 1 B2GP1, cell-membrane phosphatidylserine, and many others. Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. this drug is also effective at preventing lupus flares.

    The condition is more common women than in men, It is often found in women who have a history of repeated miscarriages. It is often found in people with other autoimmune diseases, such as systemic lupus erythematosus (SLE).

    Plaquenil prevents lupus anticoagulangpt antibodies

    Hydroxychloroquine as an anti-thrombotic in., Anti-phospholipid Antibody Testing Lupus Anticoagulant Testing

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  5. ANSWER. Not necessarily. The antinuclear antibody ANA test is positive in most people who have lupus, but it also may be positive in many people who are healthy or have another autoimmune disease. Therefore, a positive ANA test alone is not adequate for the diagnosis of lupus.

    • Does a positive antinuclear antibody test mean that I have lupus? - WebMD.
    • How is plaquenil hydroxychloroquine used to treat lupus?.
    • What Lupus Antibodies Do You Have? What Do They Mean? – LUPUS GURU.

    Hydroxychloroquine HCQ, a synthetic antimalarial agent, is currently considered as a first line treatment in SLE and its use has also been shown to reduce the incidence of thrombosis in SLE patients in general. and in those with positive aPL specifically. Conclusion Hydroxychloroquine use was associated with reduced lupus anticoagulant by seconds of prolongation and reduced titers for most of the isotypes of anticardiolipin, except for IgA. Prednisone did not reduce the seconds of dRVVT prolongation. Anticardiolipin IgA seemed the most resistant to therapy. Generally, Plaquenil® can be continued to help prevent a lupus flare. It is rare that Plaquenil causes fetal problems, and the risk of a flare outweighs the fetal risk. Prednisone also should be continued. If you are on mycophenolate mofetil or mycophenolic acid, talk to your doctor about switching to azathioprine.

     
  6. Stavrito Well-Known Member

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  7. Toshiya Guest

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  8. Nick80 New Member

    Plaquenil - FDA prescribing information, side effects and uses Jan 01, 2020 If cardiotoxicity is suspected, prompt discontinuation of Plaquenil may prevent life-threatening complications. Plaquenil prolongs the QT interval. Ventricular arrhythmias and torsades de pointes have been reported in patients taking Plaquenil see OVERDOSAGE.

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses