Chloroquine autophagy cancer

Discussion in 'Canadian Drug' started by Lekjeogue, 01-Mar-2020.

  1. Silaev Moderator

    Chloroquine autophagy cancer


    Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities.

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    Chloroquine, which targets autophagy, has been tried in cancer trials. Ironically, it was used in tumors with very high autophagy levels, the exact opposite of ovarian cancer. Kinase AMPK, can induce autophagy in cancer cells. The induction of autophagy in U251 human glioma cell line was demonstrated by acridine orange staining of intracellular acidic vesicles, Beclin 1 induction, p62 decrease and conversion of Lc3-i to autophagosome-associated L c3-ii in the presence of proteolysis inhibitors. Chloroquine CQ and hydroxychloroquine HCQ, two antimalarial drugs, are suggested to have potential anticancer properties. in the present study, we investigated the effects of CQ and HCQ on cell growth of bladder cancer with emphasis on autophagy inhibition and apoptosis induction in vitro.

    This agent may also interfere with the biosynthesis of nucleic acids. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

    Chloroquine autophagy cancer

    Autophagy Modulation in Cancer Current Knowledge on Action., Compound C induces protective autophagy in cancer cells.

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  4. Jul 28, 2017 The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib. J. Thorac Oncol. 8, 693–702 2013.

    • Targeting autophagy in cancer Nature Reviews Cancer.
    • Chloroquine and hydroxychloroquine inhibit bladder cancer..
    • Chloroquine sensitizes breast cancer cells to chemotherapy..

    Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy. Jul 15, 2014 Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS.

     
  5. micky80 Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. HYDROXYCHLOROQUINE - ORAL Plaquenil side effects, medical. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Naproxen Oral Route Side Effects - Mayo Clinic
     
  6. This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Hydroxychloroquine toxicity - EyeWiki Hydroxychloroquine-Induced Retinal Toxicity - American. Rates and Predictors of Hydroxychloroquine Retinal.
     
  7. kasper13 New Member

    Hydroxychloroquine sulfate C18H28ClN3O5S - PubChem Hydroxychloroquine Sulfate is a synthetic derivative of quinolyl with chemotherapeutic and antibiotic properties, Hydroxychloroquine Sulfate acts against erythrocytic malarial parasites Plasmodium vivax, ovale, and malariae by concentrating in food vacuoles.

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  8. Treatments for Rheumatoid Arthritis If you are taking hydroxychloroquine over a long duration, it is important to take eye exams every 6 to 12 months. 6 Do not take hydroxychloroquine if you experience vision symptoms, including problems seeing or reading, light sensitivity, blurred distance vision, or light flashes or streaks.

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