Pregnant women and chloroquine

Discussion in 'Canada Pharmacy' started by mik2005, 09-Mar-2020.

  1. s_kolenko User

    Pregnant women and chloroquine


    While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta.

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    Hydroxychloroquine Pregnancy Warnings Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. There are no controlled data in human pregnancy. Therapeutic monitoring of chloroquine was carried out in pregnant women with confirmed laboratory and clinical malaria after administration of 10 mg/kg body weight of the drug at 0 and 24th hour. Chloroquine, mefloquine are safe in pregnancy, doxycycline is not. While chemoprophylaxis in pregnancy appears efficacious, a major question remains—which agents are safest for both the woman and fetus? Some drugs routinely used in nonpregnant individuals should not be offered to pregnant women because of known direct effects on the fetus.

    Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area.

    Pregnant women and chloroquine

    Repurposing of the anti-malaria drug chloroquine for Zika., Therapeutic monitoring of Chloroquine in pregnant women.

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  5. Anti-malarial drugs hydroxychloroquine, chloroquine are considered pregnancy category C drugs. While there is evidence of risk for damage to the eye and ear, if the benefits of these drugs in controlling RA symptoms are judged to outweigh the risks, they may continue to be used during pregnancy. 1,2

    • Drug Safety in Pregnant & Nursing Women.
    • What is the most effective and safe malaria prophylaxis..
    • Chloroquine for Malaria in Pregnancy - Full Text View..

    Chloroquine is also used for prophylaxis for pregnant women and non-immune individuals at risk. Dosage and administration. All dosages are described in terms of the base. Treatment. Oral administration. To avoid nausea and vomiting chloroquine should be administered after meals. For pregnant women diagnosed with uncomplicated malaria caused by chloroquine-resistant P. falciparum infection, women in the second and third trimesters can be treated with artemether-lumfantrine, and for all trimesters, mefloquine or a combination of quinine sulfate and clindamycin is recommended. Quinine treatment should continue for 7 days for infections acquired in Southeast Asia and for 3 days for infections acquired elsewhere; clindamycin treatment should continue for 7 days. Treatment for uncomplicated malaria where the above signs are absent in pregnant women is usually chloroquine for P. vivax, P. ovale, P. knowlesi and P. malariae, as well as for P. falciparum if there are no reports of this parasite being resistant to chloroquine

     
  6. Atovaquone/Proguanil (Malarone) Adults: 1 adult tablet daily. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Chloroquine Does NOT Cure Coronavirus! Dubawa Chloroquine Aralen - Side Effects, Dosage, Interactions.
     
  7. Evgeniy P. New Member

    Plaquenil. A medication for Lupus Plaquenil Hydroxychloroquine. The drug of choice for systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases.

    Medications used to treat lupus Lupus Foundation of America
     
  8. Hydroxychloroquine Uses, Dosage & Side Effects - Mar 17, 2019 Hydroxychloroquine dosing information. Usual Adult Dose for Malaria Treatment of the acute attack 800 mg 620 mg base followed in 6 to 8 hours by 400 mg 310 mg base, then 400 mg 310 mg base once a day for 2 consecutive days; alternatively, a single dose of 800 mg 620 mg base has also been effective

    Chloroquine Oral Uses, Side Effects, Interactions.