Please review the following URL and make sure that it is spelled correctly. Plaquenil is the brand name for the prescription drug hydroxychloroquine. Falciparum nf54 chloroquine Chloroquine lupus mechanism Silver chloroquine Plaquenil hydroxychloroquine may cause psychiatric side effects. The clinical presentation of the psychosis induced by Plaquenil in a patient without psychiatric past of manifestations such as delirium, hallucinations, maniac episodes or depression, may begin after an interval of a few hours to 40 days, usually regressing one week after suspension of the treatment. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Please I need to find out if anyone who has taken plaquenil has experienced back and hip pain. I started in Oct of 2011 taking 200 mg of plaquenil once a day. In April of 2012 I started taking 400 mg 2 x's a day. I did start to notice that I was having pain when I tried to sleep at night. Mostly in my arms hands and ankles. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Plaquenil and psychosis PLAQUENIL = MENTAL PROBLEMS. - Autoimmune Disorders - MedHelp, Hydroxychloroquine - Wikipedia Hydroxychloroquine hcqPlaquenil and foot pain PLAQUENIL is indicated for the treatment of acute attacks and suppression of malaria. Warning In recent years, it has been found that certain strains of P. falciparum have become resistant to 4-aminoquinoline compounds including hydroxychloroquine as shown by the fact PLAQUENIL®. Plaquenil and pain" Rheumatoid Arthritis Community.. Plaquenil - FDA prescribing information, side effects and uses. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Deficiency Of Granulocytes A Type Of White Blood Cell. Yes, Plaquenil can cause mood changes, irritability and psychosis and can worsen the existing psychosis. So yes, changing the drug may help. However, please do not change or stop the medication on your own. You need to consult a doctor and slowly be weaned off it and on to anew drug for your lupus. Hydroxychloroquine, a kind of anti-malarial, has become an important treatment for SLE in recent years. Method We want to report a 49 year-old female SLE patient, who had psychosis episode with hydroxychloroquine treatment. Result There's still risk of psychosis with hydroxychloroquine treatment from the possible mechanism.