These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Hydroxychloroquine other names What symptoms of lupus does plaquenil treat Chloroquine and hydroxychloroquine both belong to the quinolone family and share similar clinical indications and side effects, including retinal toxicity. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. If you notice any other effects, check with your healthcare professional. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Ocular side effects of plaquenil Rx Side Effects New Plaquenil Guidelines and More., Hydroxychloroquine Side Effects, Dosage, Uses, and More How does hydroxychloroquine kill malaria The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. The Risk of Retinal Toxicity with Plaquenil. Plaquenil Side Effects on Your Eyes and Vision. Common and Rare Side Effects for Plaquenil Oral. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. The reports on ocular side effects from the usage of sulfasalazine are relatively few, despite its commercialization for a long time; the drug is generally considered safe and well tolerated. 47 There has been a report of peripheral facial nerve palsy and blurred near vision in association with sulphasalazine treatment. 48 Santodomingo et al. Chloroquine Ocular Side Effects. Chloroquine is especially absorbed by the pigment cells in the eye. Eye side effects are serious and can result in loss of vision. The side effects may occur at anytime. The higher the dose and the longer the time of use makes it more likely to occur.