Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Uptodate hydroxychloroquine Figuring hydroxychloroquine dossage Is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Activity in vitro and in Clinical Infections Hydroxychloroquine is active against the. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Activity in vitro and in Clinical Infections PH of food vacuole of plasmodium specie is acidic while chloroquine is a weak base, leading to change in pH of food vacuole. After entry, outer layer of food vacuole becomes water soluble non-lipid soluble so trapped inside food vacuole. 2. Hemozoin affinity for chloroquine Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Chloroquine weak base Chloroquine Modes of action of an undervalued drug., Hydroxychloroquine Tablets - FDA prescribing information. Hydroxychloroquine blog Because chloroquine is a weak base, it increases vesicle pH by that mechanism in chloroquine-susceptible and resistant parasites and mammalian cells based on its two pKs and on the delta pH between the acid vesicle and the extracellular environment. Basis of antimalarial action non-weak base effects of.. Chloroquine – howMed. Events - On the mechanism of chloroquine resistance in.. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Activity of chloroquine and other weak bases, with theconcentration ofchloroquine in the parasite yes-ide reported by Aikawa 14,and with the swelling of the parasite vesicle described by a numbet of Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Although these drugs are known to accumulate by a weak base mechanism in the acidic food vacuoles of intraerythrocytic trophozoites and thereby prevent hemoglobin degradation from occurring in that organelle, the mechanism by which their selective toxicity for.