Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine resistant vivax malaria treatment 25 μm chloroquine diphosphate Plaquenil and dry eyes Aug 14, 2017 Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Plaquenil. Uses. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of. Side Effects. Precautions. Interactions. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Side effects of plaquenil on eyes Plaquenil side effects? - HealthBoards, Common and Rare Side Effects for Plaquenil Oral Skin changes with plaquenil Plaquenil is a drug used to treat Rheumatoid Arthritis and Systemic Lupus Erythematosis. It is a very good drug and gives many patients significant relief from their symptoms. Plaquenil related eye complications are not common. Plaquenil can produce pigment changes in the macula of the retina. Conditions Plaquenil-related Eye Problems Eugene Eye Care. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Side effect question for plaquenil/ eyes DailyStrength. Aug 29, 2014 This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The side effect that is of greatest concern is retinal toxicity. I was just talking to my rheumatologist today. She has prescribed plaquenil. She said very rare side effect is some sort of deposits on the eye. I would contact your dr to be on safe side. My dr said to have eye exam with dilation a few months after starting. Just tell eye dr you take plaquenil and she said they would know exactly what to look for. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.