Additionally, another exception occurred while executing the custom error page for the first exception. Chloroquine retinopathy, is a form of toxic retinopathy (damage of the retina) caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine drugs.com Sunspots and plaquenil The risk of developing retinal toxicity has been found to be dependent on the daily HCQ dose and the duration of use. The risk of retinal toxicity is 1% for those who use HCQ for up to 5 years and 2% for those who use HCQ for 5–10 years, but it rises to almost 20% after 20 years of HCQ use. Hydroxychloroquine is associated with long-recognized retinal toxicity. 2,3,4 The retinopathy is hallmarked by parafoveal changes within the retina. Early toxicity may be asymptomatic, detected. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. The risk of toxicity is low for individuals without complicating conditions during the first 5 years of treatment using less than 6.5 mg/kg/day of hydroxychloroquine or 3 mg/kg/day of chloroquine, and/or cumulative doses of less than 1000 gram and 460 gram (total dose), respectively. This eye toxicity limits long-term use of the drugs. Retinal toxicity hydroxychloroquine New Screening Guidelines for Hydroxychloroquine Toxicity, New Guidelines for Hydroxychloroquine Visual Screening Generic name of plaquenilChloroquine-resistant malaria is now widespread in africaSide effects of taking too much plaquenilDoes plaquenil cause melasmaHow to stop taking hydroxychloroquine H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be. Retinal Physician - Hydroxychloroquine Maculopathy An Update.. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Multimodal Imaging in Plaquenil Toxicity. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease.