It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. What is the use of chloroquine phosphate Plaquenil myalgias Hydroxychloroquine sulfate answer 3 Some common RA medications may also contribute to sleeplessness. One is the steroid prednisone, which can cause insomnia, agitation or depression. Taking it earlier in the day is best, says Dr. Rosian. Another is hydroxychloroquine Plaquenil. It can sometimes causes people to get jumpy, nervous and twitchy. Fragmented Sleep May 23, 2016 What is Plaquenil and what are its benefits for Sjögren’s patients? Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. May 05, 2010 None of these meds make me fatigued. I believe its the illness that causes my fatigue and my daughters fatigue. I suspect that holds true for you too. Maybe someone else will tell you differently, but I haven't known anyone else that found Plaquenil to make them tired. Pace and rest when you can and if you can exercise a little try to do that. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Can plaquenil cause tiredness Plaquenil Side Effects Common, Severe, Long Term -, Ask the Expert Plaquenil and Sjögren’s Hydroxychloroquine and chloroquine comparisonChloroquin mechanismCan i take tylenol and plaquenil together Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. Medications That Make You Tired. Common culprits and what you can do. Pharmacy and Medication Tips. Common and Rare Side Effects for Plaquenil Oral. Does Plaquenil cause fatigue or fever? - Rheumatoid Arthritis. Plaquenil and Depression/Anxiety - Symptoms and Medical.. May 25, 2010 Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. You expect to feel tired if you take a sleeping pill, but other kinds of medications can cause fatigue, too. It’s one of the most common side effects of prescription and over-the-counter. It is unusual for plaquenil to cause muscle weakness, although it has been reported. I do not know what other medications your taking, which might have similar side effects. It is much more common to cause fatigue and ataxia, which might be mistaken for muscle weakness, but I will assume that your experiencing muscle weakness.